Base de connaissances
Comprendre les concepts des soins holistiques
Du système endocannabinoïde au microbiome cutané — des définitions claires et fondées sur des preuves des concepts utilisés dans nos produits et dans l'analyse de la peau.
Biology
- The endocannabinoid system is a signalling network that regulates balance in immune function, inflammation, pain, appetite, sleep and skin function. In the skin, CB1 and CB2 receptors are present in keratinocytes, sebaceous glands and hair follicles.
- The ECS is one reason CBD and CBG work topically — they are natural ligands for the body's own receptors. A balanced ECS self-regulates sebum, inflammation and barrier function. Dysregulation is linked to acne, rosacea and eczema.
- En savoir plus sur le concept
Skin microbiome
- The skin microbiome is the ecosystem of bacteria, fungi and viruses that live on the skin's surface. A balanced microbiome produces antimicrobial peptides and maintains low skin pH.
- A healthy microbiome is dominated by commensals like Staphylococcus epidermidis and Cutibacterium acnes (in proper balance). Disruption (dysbiosis) is linked to acne, rosacea, eczema and atopic dermatitis. Over-use of antibacterial products, surfactants and fragrances damages the microbiome (Byrd et al., Nature Reviews Microbiology 2018).
Gut-skin axis
- The gut-skin axis is the documented two-way link between gut microbiome balance and skin inflammation. Gut disturbances produce measurable differences in skin conditions.
- People with acne, rosacea and psoriasis frequently show altered gut flora (dysbiosis). Probiotics and fibre-rich diets improve skin conditions in controlled trials. The 1753 skin analysis weights gut health as 30% of the lifestyle score (Salem et al., Front Microbiol 2018).
Malassezia
- Malassezia is a group of yeasts that live naturally on almost all human skin. Out of balance, they cause dandruff, seborrhoeic dermatitis and fungal acne-like rashes.
- Malassezia feed on sebum fatty acids. When the barrier is compromised or sebum oxidised, they can overgrow and trigger inflammation. This is why some acne types don't respond to conventional acne creams — they need antifungal treatment instead.
Keratinocyte
- Keratinocytes are the dominant cell type in the skin, producing keratin protein and forming the protective barrier. They make up about 90% of cells in the epidermis.
- Keratinocytes form in the basal layer and migrate upward over 28–40 days before shedding as dead skin cells. Disrupted turnover (in psoriasis, sun damage, ageing) produces dry, rough or inflamed skin.
Sebocyte
- Sebocytes are the cells in sebaceous glands that produce sebum — the skin's natural mix of triglycerides, wax esters and squalene.
- Sebum protects the skin from dehydration and acts as an antimicrobial barrier. Over-production is central to acne. CBD has documented sebostatic action on human sebocytes (Oláh et al., J Clin Invest 2014).
Ingredients
CBD (Cannabidiol)
- CBD is a non-psychoactive molecule from industrial hemp that interacts with the endocannabinoid system. In skincare it is used for its anti-inflammatory, sebum-balancing and barrier-supporting properties.
- 1753 SKINCARE uses CBD at clinically relevant concentrations (0.2–10%), not the trace amounts typical in mass-market products. Peer-reviewed evidence shows effects on sebocytes (Oláh et al., J Clin Invest 2014) and on skin immune function. CBD from industrial hemp with <0.2% THC is legal throughout the EU.
- En savoir plus sur le concept
CBG (Cannabigerol)
- CBG is the mother cannabinoid from which other cannabinoids are synthesised in the hemp plant. In skincare it is used for its strong antioxidant and calming effects.
- CBG is more expensive to extract than CBD because the plant converts it into other cannabinoids as it matures. 1753 SKINCARE uses CBG at 0.2–5% depending on the product. TA-DA Serum contains 3% CBG (1 500 mg per bottle).
- En savoir plus sur le concept
Jojoba oil (Simmondsia chinensis)
- Jojoba is not an oil but a liquid wax ester, structurally very similar to human sebum. It is non-comedogenic (rating 0–2) and barrier-compatible.
- Jojoba's chemistry (wax esters instead of triglycerides) means it doesn't go rancid, penetrates the upper skin layers and doesn't clog pores. That is why 1753 uses organic jojoba as a carrier in every oil — it works for both acne- and dry-prone skin.
Diagnostics
Fitzpatrick scale
- The Fitzpatrick scale classifies skin type into six groups (I–VI) based on melanin content and UV reactivity.
- Developed in 1975 by dermatologist Thomas B. Fitzpatrick at Harvard to determine correct UV dosing in PUVA therapy. Type I is the fairest (always burns, never tans), type VI the darkest (deeply pigmented, rarely burns). The 1753 skin analysis estimates Fitzpatrick type automatically from your photo.
- En savoir plus sur le concept
Philosophy
Holistic skincare
- Holistic skincare treats diet, sleep, stress, movement and gut health as primary factors for skin health. Products are a complement, not the main treatment.
- Rooted in the view that skin is a mirror of underlying biological processes. Studies show that less than 6 hours of sleep measurably elevates cortisol and impairs skin regeneration within 48 hours. 1753's entire philosophy builds on this.
Envie d'en savoir plus ?
Lisez nos guides ou essayez notre analyse de peau gratuite fondée sur les mêmes bases scientifiques.